Getting rigorous with scientific rigor

نویسنده

  • Lorne J Hofseth
چکیده

Two of the cornerstones of science advancement are rigor in designing and performing scientific research and the ability to reproduce biomedical research findings. The application of rigor ensures robust and unbiased experimental design, methodology, analysis, interpretation, and reporting of results. When a result can be reproduced by multiple scientists, it validates the original results and readiness to progress to the next phase of research. This is especially important for clinical trials in humans, which are built on studies that have demonstrated a particular effect or outcome

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New Initiatives to Improve the Rigor and Reproducibility of Articles Published in Circulation Research

The rampant irreproducibility of scientific articles is arguably the most serious problem that bedevils biomedical research. It is a veritable plague that undermines the credibility of published studies, hinders clinical translation of basic work, and impedes the progress of medicine. Disquietingly, the problem seems to be getting worse rather than better. Although the causes of irreproducibili...

متن کامل

New Initiatives to Improve the Rigor and Reproducibility of Articles Published in Circulation Research.

The rampant irreproducibility of scientific articles is arguably the most serious problem that bedevils biomedical research. It is a veritable plague that undermines the credibility of published studies, hinders clinical translation of basic work, and impedes the progress of medicine. Disquietingly, the problem seems to be getting worse rather than better. Although the causes of irreproducibili...

متن کامل

Scientific rigor through videogames.

Hypothesis-driven experimentation - the scientific method - can be subverted by fraud, irreproducibility, and lack of rigorous predictive tests. A robust solution to these problems may be the 'massive open laboratory' model, recently embodied in the internet-scale videogame EteRNA. Deploying similar platforms throughout biology could enforce the scientific method more broadly.

متن کامل

RRIDs: A Simple Step toward Improving Reproducibility through Rigor and Transparency of Experimental Methods

With the call for more rigorous scientific reporting, authentication, and transparency from the scientific community and funding agencies, one critical step is to make finding and identifying key resources in the published literature tractable. We discuss here the use of Research Resource Identifiers (RRIDs) as one tool to help resolve this tricky problem in reproducibility.

متن کامل

Rigorous Science: a How-To Guide

Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word "rigor" is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 39  شماره 

صفحات  -

تاریخ انتشار 2018